A newspaper ad placed to locate a certain doctor sets off the murder of several people with the same face. When Scully and Mulder locate another look-alike, they must reach him before the killer does. Meanwhile, Mulder is distracted from the case with the sudden reappearance of his sister Samantha.

Ash's case finally comes to trial and Matt has an important decision to make. Jude's personal and professional lives collide when a young man with AIDS is rushed into casualty.