A group of lonely women cast a spell that turns animals into men, with predictably bad results the citizens of San Francisco. In addition to a terrorized town, Prue is also depressed about being unemployed.
Rachel forces Ross to cancel his date with her sister. Phoebe discovers she's being mistaken for a porn star. Chandler admits he hasn't been able to cry since he was a child.
It's Valentine's Day in the ER. However it proves to be a tough day when Chen and Malucci clash over the treatment of a patient, the parents of two young children die in a car accident, Lucy and Carter treat a law student who she believes may have mental problems, Romano and Elizabeth operate... on his dog, and Abby learns that not all ER cases have happy endings when she treats a dying elderly woman. Mark and Elizabeth go out on a double date with her mother and his father. At the end of the day, the staff party, unaware that Carter and Lucy have both been stabbed by Lucy's patient.
Betty picks up Armando and when he is unable to get into Ecomoda to get his clothes, Betty takes him home and Julia and Betty try to help him. Hermes gets up and they hide Armando, but his cell phone rings.