An attempted assassination of the sisters leads Prue to go undercover as the woman responsible, who goes by the name of Ms. Hellfire. While undercover, she becomes romantically entangled with the man who put the hit out on them in the first place.
Lucy struggles to get patient Valerie in for surgery when an infection threatens her heart transplant. Carter and Chen disagree over the treatment of an elderly woman and her care-giving daughter. Mark tries to help an abusive gay couple. Carol has trouble adjusting after her return from maternity leave. Dr. Dave goes out of his way to shut an illegal pharmacy down. Luka treats some circus performers. The ER suffers from a water shortage. Benton asks Cleo out.
Betty receives the sales reports and asks Patricia to reconfirm Armando's return for the next day. Betty does not approve of Hugo hiring models for sizing and they rebel against her. When Armando arrives and considers the situation so serious, he asks Betty for a loan for Ecomoda.