As they drive into town, Willow and Faith find themselves behind a truck. A young girl is thrown out with a deep wound and the truck drives off. The girl is unconcious so they take her to the hospital and report to Buffy. Faith's arrival brings a lot of tension to Buffy's house. All the potentials ask questions, but Faith is only interested in talking with Buffy. They clear the air and then receive a phone call from the hospital. The girl is called Shannon, she tells Buffy about a young preacher that saved her from bringers. He then called her dirty, branded her with his ring and stabbed her. Willow takes a photo of the mark from the ring. Shannon mentions the man's message; that he has something that belongs to Buffy.
When a meeting of the Edgar Allan Poe Society at the Independence Inn is interrupted by a fire, Lorelai must find rooms for the guests at various homes around town. Forced to give up her own room, Lorelai spends the night at Luke's. Trying to decide among Harvard, Yale and Princeton, Lorelai and Rory make an extensive list of pros and cons for each school. Luke worries that Jess may be skipping school when he learns that Jess has been working a surprising number of hours at Wal-Mart. Rory visits a humiliated and hibernating Paris to deliver school assignments and a pep talk.
After a schoolmate claims to be an alien and proves it by using heat vision, Clark investigates and believes the boy is from Krypton. Meanwhile, Helen confronts Lex over the locked room in the mansion that holds his investigation of Clark's secrets.
On April 25, 1953, James Watson and Francis Crick published their groundbreaking discovery of the double helix structure of DNA, the molecule essential for passing on our genes and the ''secret of life'.' But their crucial breakthrough depended on the pioneering work of another biologist?Rosalind Franklin. She would never know that Watson and Crick had seen a crucial piece of her data without her permission. This was an X-ray image, ''Photo 51',' that proved to be a vital clue in their decoding of the double helix.