The Camden chaos continues with Matt (guest star Barry Watson), who is trying to salvage his marriage, questioning whether he still has feelings for his ex-girlfriend Heather (guest star Andrea Ferrell); Simon's (guest star David Gallagher) return to Glenoak creates conflicted feelings for his ex-girlfriend Cecilia, who is torn between her feelings for Simon and her current boyfriend Martin; Ruthie's foreign exchange student friend Maria (guest star Samantha Sandoval), appears to be making the moves on Ruthie's boyfriend Peter; and grandparents-to-be Eric and Annie hop a plane for New York, despite Mary's (Jessica Biel, who does not appear in the episode) repeated pleas for her family to stay away during labor.
Beka decides to leave the crew to fight for themselves, but after all of the promises that everyone will be reunited, Trance tells them that they will never be as they are again. When the Magog Worldship finally re-encounters the Andromeda after two years, Rommie and Harper race to take the Arkology to slipstream, Rhade must teach the inhabitants to defend themselves, and Dylan and Trance fight off the invading Magog. But as the Andromeda becomes covered in swarmships, Trance tells Dylan that he - and only he - may escape this alive.
Ryan will sit down with the judges one on one to learn what they think about this season, and then Diana, Fantasia and Jasmine will sing one song each!.
When a teenage girl returns home from a big party night at an underage nightclub to find her parents murdered, the search for the killer leads Horatio to New York City. Before he arrives, the New York detectives, led by Detective Mac Taylor, are called out to investigate the shooting of an undercover police officer who, it turns out, is the lead suspect in the Miami case. However, the medical examiner determines that he has been dead for 72 hours and could not even have been alive at the time of the double-murder in Miami. After further investigation, Horatio and Mac determine that the real killer murdered the New York cop, then used his ID to get to Miami, and is still on the loose.
A monstrous amount of counterfeit $100 bills show up everywhere at the Montecito. Danny and his newest partner, Mike, try to find the source of the fake money. Danny gets some unpleasant news and Mary gets a surprise, and unwelcome, visit from her father.
At Ed's suspension hearing, Chrissie refuses to cover for him and Tom, Ric and Zubin try to separate conjoined twins. When problems arise, Tom tries to get the permission of the parents to continue but when he fails to he continues anyway which results in him having to resign. Meanwhile, Lisa is offered the position of Ward Sister on Keller.
