When Joe suddenly falls violently ill, the group becomes alarmed. Meanwhile Erika discovers an antidote, but refuses to give it to Joe unless he comes clean about his secret. Elsewhere, reporter Renbe and Kat attend Tori's funeral in Rome and discover that her father, the U.S. ambassador to Italy, is also investigating her disappearance.
The staff find out about Lola's brain tumor; Briggs questions Glenn about his medical treatments; a boy who's aging too quickly comes in to the hospital; and Blake tries alternative medicine.
Iron Chef Hiroyuki Sakai was a guest judge for the invention test. The core ingredient was crustaceans and the contestants, working in two teams, had to cook a banquet.
The team attempt to build some interesting motor homes before setting off for a Bank Holiday weekend in the West Country to see how what that they have created holds up. Jeremy test drives the new Audi R8 V10 Spyder and the latest version of Porsche's enduring 911 Turbo cabriolet to see how they compare.