The season opener finds Michael Scofield in Sona, a hellish and deadly Panamanian prison where a previous riot has forced all authority out and has left the prisoners in charge of their own lives (and deaths). With the fate of his loved ones hanging in the balance, Michael must to find Whistler, a mysterious fellow inmate hiding within the prison's sewer system, in order to break him out from a prison from which there is no way out. Meanwhile, Lincoln searches for a missing Sara and receives troubling news about LJ.

In the wake of the storm, NOPD officer Marlin Boulet attempts to rescue survivors, while his partner, Charlie Pratt, gets scared and takes off.

Tony Bourdain has missed out on the culture and history of South Carolina because he's never traveled there before. Will he find the delicious cuisine and Southern hospitality it's known for?

Silas makes a new friend; Nancy's conflict with Conrad and Heylia comes to a head; and Nancy finds herself charged with the task of making peace between Agrestic and Majestic.

Heidi tries to fit into her new job. Meanwhile Lauren has to decide if she will give Jason another chance.

A crime from 11 years ago is on Grace's thoughts due to a new case.

Hank spends the night with a sexy surfer girl and in return she robs him.

Mia wants more of Hank's writing to pass her class, instead he offers her to help her with her own writing.

Charlie wants to spice up the sex life with his wife, but she is not as fond of spanking as Dani is.

Sam realizes he might come his dream to hike the Appalachian Trail a little closer, when Juicy Lou shows up and offers to buy the shop. However, Sam's employees start to beat Juicy Lou's offer.

Ellen gets some bad news from her parents. Arthur Frobisher and his team do everything they can to keep things going their way while a witness remains missing.

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Nikki's reconstruction of the old crime scene delivered a devastating blow - doubts she had over the previous case were confirmed. When her father unwittingly leaked the story to the press, her professional integrity hung in the balance.

Harry's investigation into the decomposing bodies of two teenage girls led him back to the Anna Holland case - and his findings ultimately exonerated Anna Holland. The hunt for Anna's killer continued to draw blanks until the team received some shocking news. The badly burned woman in the hospital was not Carla, but Anna - which meant it was not Anna, but Carla who was murdered.