The trampling death of a trainer by her horse aboard a private jet is investigated by Grissom, Catherine, and Nick. Sara and Warrick look into a Romeo and Juliet scenario in the desert.
Will reluctantly opposes Karen when he represents her husband while she hires a goofy, immature young man who seems barely out of high school to argue her case -- and Will takes pity on the pseudo-slacker. Elsewhere, Grace hires Jack to temporarily replace Karen but finds she might have to choose between her friendship with him and a wealthy client who broke his heart.
Kovac defies the rules to get a dying Croatian boy to Chicago in a race to save his life. Despite receiving tragic news, Carter tries to prevent grieving gang member Curtis from seeking vengeance. Carter's sad family gathering is interrupted by Abby's mentally troubled brother Eric, who has left his voluntary care facility. Meanwhile, Lewis has trouble ending her relationship with Chuck. Perez, a baseball player with a serious heart ailment, is treated on the eve of his pitching debut with the Chicago Cubs. And a tormented Romano makes a dramatic decision about his mangled arm, after it catches fire in his kitchen. Luka departs for the Congo after saying goodbye to Abby.
Jack's methods in the investigation of child molester could result in the case being kicked out of court. Then, on top of that, the Office of Professional Responsibility decides to investigate the team, but their real target is Jack.