The medical examiner determines that the bad package which killed five inmates and hospitalized eight others was cut with strychnine, so the heat is on to close the case quickly; as the pressure mounts to deliver Omar's testimony in the Gant case, McNulty enlists Bubbles in the search, but an unhappy Omar finds Bubbles first; Dee confronts Avon about the bad package and washes his hands of the business; Daniels and Burrell strike a deal on the detail, but Rawls refuses to reassign McNulty while okaying Greggs, Hauk and Lester; Stringer continues to struggle with poor quality product from his suppliers; Avon brokers a deal to give up Tilghman for a reduction in his sentence; McNulty continues his efforts to identify his floater; pleased with the outcome of their prior deal, the Greeks come to Nick and Ziggy with a request for bulk chemicals; after Sobotka chews Nick out for stealing the container and tells him to keep a low profile, Nick passes the word to his cousin, which falls on deaf ears; Daniels and Greggs get the silent treatment in their respective homes after they break the news of the new detail to their wives; McNulty signs the separation papers as he asks Elena for another chance; Bunk, Lester and Russell terrify Sobotka when they drop by the bar for a little quality face time.
Carrie has a hot date with Jack but worries the entire time that she'll screw it up. To calm down, the girls suggest that she has a "sim-u-date" prior to her date with Jack. Though the "sim-u-date" doesn't go well and Carrie runs into Aiden, she decides to still go on her date with Jack. Meanwhile, Charlotte is still in love with Harry, and Harry still refuses to marry a non-Jew. Miranda admits her feelings for Steve, but is crushed when she finds out that he's in a relationship. Samantha sleeps with her new stockbroker neighbor and he gives her stock tips.
Queer as Folk's Third Season Finale starts with only a few more days untill a new mayor is selected and Brian realizes that he must do something to stop Stockwell. A thing Justin also sets in motion by saying there should be a real rage, who could change everyone's mind about Stockwell.
After stealing a large amount of money from a bank a man is found crucified on the moors. The Treasury calls in the team to investigate but when Harry decides to take the mission further Danny's life is put in danger.