Although she is worried about the lesson plan for the class she is teaching on abstinence at the church, Lucy is excited when Eric tells her she is now the Associate Pastor and will soon give her first sermon this coming Sunday. Meanwhile, Simon begins to go see Eric's former therapist Dr. Gibson (guest-star David Piel) to help deal with some personal issues. During one of the sessions Simon realizes he has been using his relationship with Georgia (guest-star Rheagan Wallace) to block out the guilt he still feels about the fatal car accident that happened last year. Lastly, Ruthie falls for a guy she meets in detention, Harry (guest-star Aaron Carter), a foster kid currently living in a county facility. Even so, Martin has reservations about the situation and keeps a watchful eye on the couple despite Eric's approval when Harry comes over to the house.
Ephram regrets promising Nina that he would watch over Hannah at school, especially when her constant presence interferes with his time alone with Amy. Amy befriends Hannah out of a sense of charity, but soon finds Hannah so refreshing that a real friendship develops. Meanwhile, Andy tries to ignore the tension between Dr. Abbott and Edna, but his attitude forces Edna to quit and go to work for Dr. Hartman. Andy treats a 13-year-old patient (guest-star Carter Jenkins) whose mysterious injuries cause Andy to suspect the boy's mother (guest-star Elizabeth Mitchell) of abuse.
A woman is killed during a party at a Star Island estate when a man opens fire on the proceedings from a cigarette boat. When a former con is arrested, he acts as his own lawyer and proves to be smarter than he appears. Complicating matters is the fact that the leading witness in the case is the dead woman's young son, who Horatio wants to protect, refusing to let him testify.
When Ed is framed for murder of an ex CIA partner Mike and Danny must investigate in order to clear their boss's name. Sam, Delinda, Mary and Nessa try to rent out their new home, they find what they think are the perfect couple but are they really who they look like?