Carlos is bitten by a mysterious insect while investigating an outbreak of Crimean Congo Hemorrhagic fever; Wes's pregnant niece is hailed by religious fanatics as the next Virgin Mary; Wes unwittingly flips out on ergot, a natural source of LSD.

The spectre of disloyalty among the crew hangs over Tony as Phil Leotardo decides how to handle recent issues with the Soprano crime family; a hit gone wrong comes at a huge cost; A.J'.s conquering of his depression is challenged

The boys go ahead with their plan to smuggle marijuana across the border using a model train. What could possibly go wrong?

Nick's friends persuade him to move out of the house. Nick decides to check out a college. Sophie, Shannon and Gene go shopping to buy items for Nick to bribe him into staying home. Nick has a terrible experience at the weekend orientation. Sophie asks Nick not to tell their parents about his experience so that his parents will continue to bribe him into staying home.

Vince, Eric, Drama, and Turtle are forced to move out of the mansion. Eric moves in with Sloan and Drama wants to get an expensive condo. With "Medellin" getting into the early stages of pre-production, a surprise cast member is asked to direct

Paris and Nicole try to help the campers of Camp Shawnee get into shape. They show the female campers how to loose weight 'their' way and the girl and boy campers go into competition on who can loose the most weight. Nicole gives Hunter tips on impressing Paris. Hunter later finds out that Paris doesn't impress easily.

The unthinkable comes to pass, Cardinal Wolsey is stripped of his powers and authority. No longer is he the Lord Chancellor.

His successor is a surprising choice.

Roxy is trying to get used to her new life as an army wife. She learns that the community's first impression of her isn't the one she planned.

Tom is set a challenge of getting to Spain in under 24 hours in a BMW touring car. Jason gets to drive the Aston Martin V8 Vantage Roadstar.