Sherry's meddling in Daphne's personal life hits a new low when she hands out Daphne's phone number to strangers. Daphne makes Niles' dreams come true when she seeks refuge from Sherry at his home.

The Mayor separates from his wife and moves in with Michael, much to Mike's chagrin. Meanwhile, designer Isaac Mizrahi helps the Mayor's office with a charity fashion show and gives Nikki a once-in-a-lifetime chance to strut the runway in one of his creations.