As Wolf deals with a personal crisis that brings up dark corners from his past, the interns assist an MMA fighter exhibiting strange symptoms. Meanwhile, Pierce is visited by Bitsy, an Upper West Side housewife with a penchant for gossip, who gives her some shocking intel about a nearby influential surgeon.

A reality show contestant lands at the hospital with an unusual delusion. Dr. Pierce fights for her future at Bronx General. Wolf clashes with Frederick over a personal matter.

Dr. Wolf and his team treat a young patient accused of a serious crime. Dana navigates unfamiliar territory in the romance department. Pierce returns to work.

Dr. Wolf and Dr. Pierce are tasked with a house call to evaluate a woman under a conservatorship. Dr. Kinney's curiosity is piqued by a patient outside the hospital.

When two patients arrive in critical condition, Dr. Wolf and Dr. Nichols must do whatever it takes to keep them alive.

Dr. Wolf is haunted by a ghost from his past. A patient arrives at Bronx General who appears to have risen from the dead.

A blast from the past shakes up Dr. Wolf's world when he becomes his next patient.

On a flight gone wrong, one patient's life is literally turned upside down.

Wolf treats a heroic firefighter who struggles to share his ALS diagnosis with his family.

Dr. Wolf helps a ballerina recover after a mystery illness; the team tries to save Sam's life and get him on the transplant list; secrets are revealed at the hospital's annual holiday gala that change the course of the doctors' lives.

Dr. Wolf and the team come together as one of their own fights for their life.

A rugged cowboy struts into Bronx General with mysterious symptoms and brings the rodeo with him; Dr. Wolf develops a relationship with someone who has ties to his father.

When a college student comes in with a life-threatening illness, Dr. Wolf and his team have to get acquainted with sorority life. Dr. Thorne treats a child who collapsed under mysterious circumstances.

A grisly accident puts everyone at Bronx General in danger and leads to a shocking revelation about Dr. Wolf.