After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

A tragic passing rocks the team at Grey Sloan in more ways than one as they navigate a chaotic first day of surgical rotations amid hospital renovations and memorials. Meanwhile, Meredith spends time with Amelia.

A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance, Lucas' war with Wes begins to impact his decision making, Teddy takes her mind off things by assisting Jo with car sale negotiations, and Kwan gets off to a rocky start with new plastics fellow Dr. Mohanty.

The interns juggle a bizarre trauma, Teddy begins to appreciate her circumstances, while a complex breast reconstruction forces Meredith into a tense partnership.

Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.

Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey's patience.